Metabolic alterations of the gut-liver axis induced by cholic acid contribute to hepatic steatosis in rats
Researchers believe GLP-1 receptor agonists may modulate dopamine pathways, diminishing the reward response that drives most forms of addiction
(126) showed that GCK could alleviate arthritis in AIA rats by inhibiting T cell activation, and the mechanism was through inhibiting T cell proliferation, CD25 expression and IL-2 production, as well as up-regulating immature T cells and Treg cells in the spleen, thus exerting immunomodulatory effects on RA model to improve arthritis
KeslSLPoffAMWardNPFiorelliTNAriCVan PuttenAJet alEffects of exogenous ketone supplementation on blood ketone, glucose, triglyceride, and lipoprotein levels in sprague-dawley rats
6.2 Amino acid metabolism and oxidative stress response Glutamate metabolism is also critical for meningococcal virulence, linking carbon and nitrogen utilization to the oxidative stress response
Herein, we describe the discovery of the orally bioavailable, small-molecule, GLP-1R agonist PF-06882961 (danuglipron)
