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Several recent studies have pointed out that alterations of the gut microbial tryptophan metabolism influence peripheral Trp availability, affecting central tryptophan levels and, thereby, leading to changes in the central serotonin metabolism (171, 172)

Shao and colleagues discovered that GLP-1 administration restores the balance of inhibitory signaling by enhancing GABA release, thereby promoting RGC survival and improving visual function in early DR

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Most patients see a 5 to 8% total body weight loss over 12 months

Certain events initiate morphological alterations that compromise RBC viscoelasticity and induce osmotic fragility 15,16,17,18 , ultimately promoting erythrophagocytosis by residential macrophages 19