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Similarly, T47D cells have also previously been reported to be devoid of mature GSTO1 (ref

5-12 However, in clinical trials, including SURMOUNT-1 for tirzepatide and STEP 1 for semaglutide, participants were permitted to remain on a given dose for up to 4 additional weeks, as needed, to allow for the dissipation of any GI AEs

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The present findings, therefore, suggest that sll0067 has lower kinetic efficiency than most of the mammalian GSTs as well as TeGST and SeGST