stride study semaglutide and walking capacity in people with symptomatic peripheral artery disease and type 2 diabetes (STRIDE): a phase 3b, double-blind, randomised, placebo-controlled trial The STRIDE trial demonstrated that

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Hunger and food intake may increase again, making weight maintenance more difficult

Amylin is a hormone secreted from the pancreas along with insulin after meals, which slows gastric emptying and increases satiety

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In contrast, gradual dose reduction may attenuate this effect by allowing physiological adaptation in energy balance regulation