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Author Contributions Christopher Lbker and Jens Magelund Tarp conceptualized and designed the study

A study by the same group in the longitudinal DATATOP cohort (deprenyl and tocopherol antioxidative therapy of Parkinsonism) which included individuals with early PD in a placebo-controlled clinical trial reported increased CSF pS129 and pS129/total -synuclein ratio over 2 years of disease progression (Stewart et al., 2015)

The problem is not that these formulations fail to deliver the drug