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By reducing oxidative stress in the brain, glutathione may help preserve cognitive function and protect against neuronal damage
The use of potent CYP 3A4 inhibitors with dihydroergotamine should therefore be avoided (see CONTRAINDICATIONS)
Inactivating mutations in the EPHX2 gene that encodes sEH, as well as pharmacologic inhibition of sEH, leads to the stabilization of cellular levels of EETs, as well as other epoxy fatty acids, resulting in beneficial outcomes in several conditions
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