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The synergy between these drugs creates what researchers call a dual-pathway approach

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10.3390/biomedicines12030620 131 MasiS.UlianaM.VirdisA

And so one question has come up

[25] Cancer [edit] In response to a report of precancerous changes in the pancreases of rats and organ donors treated with the DPP-4 inhibitor sitagliptin, [26] [27] the US FDA and the European Medicines Agency each undertook independent reviews of all clinical and preclinical data related to the possible association of DPP-4 inhibitors with pancreatic cancer