Leptin overexpression activates Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling, leading to the induction of suppressor of cytokine signaling 3 (SOCS-3), which inhibits IRS-1 and IRS-2, impairing downstream phosphoinositide 3-kinase-protein kinase B (PI3K-Akt) signaling essential for glucose uptake
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Circadian disruption or chronodisruption in pregnant women can lead to adverse outcomes in the offspring (61)
Other considerations include individuals with gastrointestinal issues, as semaglutide may cause nausea, vomiting, or diarrhea, especially during the initial stages of treatment