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Examples of otoprotectants include, but are not limited to, PNU 37883, AM 92016, XE-991, linopirdine, Ro 04-5595, ()-1-(1,2-diphenylethyl)piperidine, ifenprodil, SYM 2206, FPL 64176, ZK 93423, m-chlorophenylbiguanide, 2-APB, MR 16728, d-tubocurarine, berbamine, E6 berbamine, hernandezine, and isotetrandrine

In particular, combining 2-OHNA with other NAD + biosynthesis inhibitors like FK866 effectively kills NAPRT-proficient cancer cells resistant to single-agent treatments 217

Synergistic effects in combination studies can often achieve the desired outcomes with reduced dosages, which helps minimize potential side effects