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Detailed derivations are in Supplementary Methods

Nature 540:S97S97

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References Khavinson VKh et al., Bull Exp Biol Med 2003 telomerase in fibroblasts Anisimov VN et al., Biogerontology 2003 lifespan in CBA mice Korkushko OV et al., Bull Exp Biol Med 2007 elderly cohort outcomes St Petersburg Institute of Bioregulation and Gerontology research index See also our editorial coverage at PeptideAuthority.co.uk for related research dossiers

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In experimental systems, DSIP has been shown to influence second messenger activity and hormonal signaling cascades linked to the hypothalamicpituitaryadrenal axis, including regulation of adrenocorticotropic hormone and related endocrine mediators [4]