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The present data demonstrate that eliminating hepatocyte DPP4 in HFHC-fed mice decreased DPP4 activity and increased intact incretins in the portal circulation and reduced HGP

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A 2025 study in JAMA Network Open found that people with type 2 diabetes who took semaglutide (Ozempic) or tirzepatide (Mounjaro) had a 76% higher risk of developing a rare condition called nonarteritic anterior ischemic optic neuropathy (NAION)

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