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8g) and YBX1 but not PRKAA1 mRNA levels were significantly reduced (Extended Data Fig

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Several other open questions emanate from our study

Eight more mutations (H18D, H21N, R167N, K168A, D171S, K172R, E174S, and I179T) were introduced at binding site 1 on the molecule to prevent PEGylation and to increase the affinity for the receptor at this site

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