More broadly, anyone seeking treatment for obesity or type 2 diabetes should be aware that NICE-approved treatment pathways exist in the UK, including licensed medicines with established safety profiles, regulatory oversight, and clinical support structures
The limited number of patients using Mounjaro off-label for obesity is roughly on par with Ozempic persistence for type II diabetes, hovering around 45% at month 12
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Retatrutide is different
Wegovy is specifically licensed for weight loss in eligible adults and works by reducing appetite, increasing fullness, and helping regulate blood sugar
These medications mimic the natural GLP-1 hormone that helps regulate appetite, blood sugar levels, and digestion