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Tirzepatide also targets glucose-dependent insulinotropic polypeptide (GIP) receptors, which may contribute to its unique pharmacological effects

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3-adrenergic agonists enhance thermogenesis by activating Uncoupling Protein 1 (UCP1) in brown adipose tissue, which stimulates PKA-mediated lipolysis and increases energy expenditure [42]

doi: 10.1007/s00284-011-9915-3 229 ZilmerMSoometsURehemaALangelU