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Drug metabolism Compounds in grapefruit called furanocoumarins can block the function of CYP3A4, a digestive enzyme that helps the body metabolize approximately 50% of drugs

Aravinda S, Gopalakrishnan B, Dey CS et al (1995) A testicular protein important for fertility has glutathione S-transferase activity and is localized extracellularly in the seminiferous tubules

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This concern applies to all GH secretagogues, not ipamorelin specifically