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Numerous toxicity studies have been done to assess the safety of MSM and doses up to 4,845.6 mg per day (4.8 grams) appear to be safe ( However, some people may experience mild reactions if they are sensitive to MSM, such as stomach issues like nausea, bloating and diarrhea

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A distinct sequence (ATAAA)n separates methylated and unmethylated domains at the 5-end of the GSTP1 CpG island