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JAMA, 327(6), 534-545

Sahnis Maintenance Strategy At Centra Internal Medicine, we dont just stop the medication

Tier 3 patients often experience significant improvements in energy levels and brain fog within 2-4 weeks, with substantial weight loss and metabolic improvements within 8-12 weeks, and continued progress over 6-12 months

GLP-1 receptors are expressed on vascular endothelium, and GLP-1 receptor agonism has been shown to increase nitric oxide bioavailability independently of weight loss in a 2019 study published in Hypertension [12]

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