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The key principle is to reduce slowly and monitor continuously, treating any upward weight trend as a signal to pause the reduction or increase one step

GLP-1s can also promote feelings of fullness, prompting FDA to approve some drugs as weight loss agents

How do GLP-1s work

If you experience low mood, thoughts of self-harm, or suicidal thoughts, seek urgent medical help contact your GP, call NHS 111, or in an emergency call 999 Patients are encouraged to ask their doctor about the current evidence base, the distinction between trial data and licensed use, and what support will be available if side effects occur

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Thinner needles cause less discomfort but draw medication more slowly