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Having the combination of two drugs increases efficacy Adults with migraines and obesity are good candidates for this weight-loss medication Side effects include dizziness, altered taste, and insomnia Contraindications include uncontrolled hypertension and coronary artery disease, hyperthyroidism, glaucoma, and sensitivity to stimulants Naltrexone-bupropion (Contrave) - Delivered to your pharmacy, paid by you (10-100$ monthly or covered by insurance) Combines an opioid receptor antagonist with an antidepressant Decrease cravings and appetite Side effects include nausea, constipation, and headache This medication should not be prescribed to a patient who has a seizure disorder or who takes opioids for chronic pain Setmelanotide (Imcivree) - Delivered to your pharmacy, paid by you (10-100$ monthly or covered by insurance) For chronic weight management in specific rare genetic disorders Requires confirmation through genetic testing If genetic testing confirms specific gene mutation, then will start Setmelanotide, FDA approved for genetic obesity Covered by most insurance companies Orlistat (Xenical and Alli) - Delivered to your pharmacy, paid by you (10-100$ monthly or covered by insurance) Inhibits the absorption of dietary fats Side effects include oily discharge and increased defecation Metformin - Delivered to your pharmacy, paid by you (10-100$ monthly or covered by insurance Treats type 2 diabetes, and PCOS.It also helps significantly for weight management, particularly in those with insulin resistance