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While uncommon, this risk underscores the importance of receiving injections under medical supervision

This oxidative damage activates signaling pathways that promote inflammation and fibrosis, leading to glomerular hypertrophy, mesangial expansion, and tubulointerstitial fibrosis [183]

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It is hoped that tau-targeted ASOs may slow or halt neurodegeneration by preventing the aggregation of hyperphosphorylated tau into neurofibrillary tanglesbelieved to be a key driver of neuronal lossand the spreading of tau across neural networks (seeding)