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In U-87MG the metabolites that most contributed for the separation (VIP score 1) (Fig

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Under identical conditions, thioridazine gives two major products (endocyclic sulfoxide and endocyclic N -oxide with the methylsulfonyl group substituted by a hydroxyl group), similarly to fluphenazine ( N -piperazine oxide and the trifluoromethyl group substituted by a carboxyl group)

high consumption of processed and refined food, with lack of dairy and meat-based food in diet, excessive consumption of alcohol, impaired absorption from the gastrointestinal tract or impaired storage and use by liver (1)