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Metalphenolic network (MPN) coatings protect lactobacilli from gastric acidity and substantially increase mucoadhesion in the intestinal mucus layer (Gao L

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282 Although the composition of human gut microbiota remains relatively stable from around age 3, gut microbiota undergoes the increase in diversity and altered proportions of composition

Intranasal delivery offers a potential advantage: absorption through the olfactory and nasal mucosal pathways provides a more direct CNS route that partially bypasses the plasma degradation problem