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Further, inorganic nanomaterial such as manganese dioxide (MnO 2 ) nanosheets based GSH-responsive nanoprobe has been established, which comprises of fluorescence and magnetic resonance imaging (MRI) based dual imaging system [73]

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In fact, inactivation of either IGF-1 or IGF-R by knock-out is incompatible with life in the majority of the cases, and in the rest of the cases, it certainly causes infertility in both sexes with an infantile reproductive system (67)