PubMed , Journal of Medical Toxicology , vol
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Tirzepatide dosing protocol Tirzepatide follows a well-established escalation schedule refined through multiple clinical trials and years of real-world use: Weeks 1-4: 2.5 mg once weekly (starting dose) Weeks 5-8: 5 mg once weekly Weeks 9-12: 7.5 mg once weekly (optional intermediate step) Weeks 13-16: 10 mg once weekly Weeks 17-20: 12.5 mg once weekly (optional intermediate step) Week 21+: 15 mg once weekly (maximum dose) The starting dose of 2.5 mg is intentionally subtherapeutic
doi: 10.1212/CON.0000000000000715 [PubMed] 31766004 Minicucci F, Ferlisi M, Brigo F, Mecarelli O, Meletti S, Aguglia U, Michelucci R, Mastrangelo M, Specchio N, Sartori S, Tinuper P
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