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A 2005 trial in the International Journal of Cosmetic Science (Robinson et al.) ran a 12-week, double-blind, placebo-controlled test in 93 women aged 35 to 55 comparing a moisturizer containing a very small amount of pal-KTTKS (3 parts per million) against the same moisturizer without it

Most FIH trials involve healthy subjects people without the relevant condition who choose to contribute to early-stage medical research

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However, they may also refer you for blood tests if they suspect you may have a nutritional deficiency or another underlying cause