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In December 2017, Portola announced the FDA had extended its time to review the application until May 2018

One clinical study found that these tend to be mild to moderate, occurring primarily when dosage levels increased from 5 mg to 10 mg/15 mg

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Warming your medication thoroughly and extending your injection time (injecting more slowly) can significantly reduce this sensation

Obesity is a well-established risk factor for the development and progression of knee OA (KOA)