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The COVID-19 pandemic is a case in point: consider the drugs dexamethasone and baricitinib

We used greedy nearest neighbour matching with a caliper of 0.1 pooled standard deviations

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This is not an immediate change

Patients treated with dietary supplements containing alpha-lipoic acid, acetyl-L-carnitine, and a vitamin B complex (Tioneural retard), which act synergistically on inflammation of the peripheral nervous system, showed a reduction in the VAS score attributed to neuralgic discomfort