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Administer 5-Amino-1MQ concurrently or add NAD+ precursors like NMN (nicotinamide mononucleotide) at 250500 mg/kg daily

Some studies suggest the quinolinium structure is sufficiently NNMT-selective that it should not broadly deplete SAM, but the wider metabolic picture remains an active research consideration

Special monitoring may be needed for diabetes medications (though AOD-9604 doesnt affect glucose metabolism), cardiovascular drugs, thyroid medications, or other growth hormone-related therapies

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That process is slow, and for some people it is not very efficient