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During oxygenated or oxygen-deprived states, hypoxia-inducible factor 1 (HIF-1) promotes Th17 differentiation by directly transcriptionally activating RORt and facilitating the formation of a tertiary complex comprising RORt, p300, and HIF-1 at the IL-17 promoter region [41]

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Patients with active, uncontrolled hyperthyroidism should generally have their thyroid condition stabilised before initiating Mounjaro or any new medication for diabetes or weight management

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