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In a landmark study by Shain et al, some important conclusions were reached

PMID: 35002520 Cell Death Discov Pregnane X receptor protects against age-related bone loss in males via PI3K/Akt-mediated inhibition of apoptosis

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61 In addition, it was one of the most reported lean-associated genera in patients with obesity and metabolic disorders 62 and was found to decrease in patients with diabetes