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TennCare has covered GLP-1 precursors and their counterparts since they became FDA approved in 2005 as add-on therapy for diabetes management, and cardiovascular disease mid-year 2024, consistent with federal requirements and TennCare Medical Necessity Rules

Tirzepatide is an innovative investigational peptide that acts as a dual agonist of GLP-1 and GIP receptors , by targeting two key hormonal pathways involved in metabolic regulation

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Instead, the culprits appear to be: Insulin resistance Impaired insulin clearance Chronic hyperinsulinemia Key finding: Lower FEV1 and FVC were strongly linked to insulin resistance - even supported by Mendelian randomization suggesting causality

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