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We refer commenters to the testing results in this rule, as well as the results calculated using the July 2023 Overall Star Rating as reported in the CY 2025 OPPS/ASC final rule with comment period (89 FR 94514 through 94521) which produced similar findings

Translation to human clinical application remains limited

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Schoenenberger and Monnier reported in the Proceedings of the National Academy of Sciences USA the isolation, sequence determination and synthesis of the active material, identified as the nonapeptide Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, and demonstrated that intraventricular infusion of the synthetic compound in rabbits reproduced delta- and spindle-EEG enhancement under double-blind conditions (Schoenenberger & Monnier, 1977)