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These structural data reveal a binding mode largely consistent with native amylin, but with notable differences: cagrilintide anchors via the F23 residue and forms a distinctive E14R17 intramolecular salt bridge that stabilizes its receptor-bound conformation
Comparative work with the individual components provides direct measurement of how dual-mechanism engagement compares to single-mechanism pharmacology
By activating these receptors in the brains satiety centers (like the area postrema), it promotes feelings of fullness, reduces food intake, and helps stabilize post-meal blood sugar spikes, making it a promising candidate for weight management, particularly in combination with the GLP-1 receptor agonist semaglutide (marketed as CagriSema)