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Oocyte aging as a redox imbalance phenomenon Reactive oxygen species are oxygen-containing free radicals with an unstable structure, making them highly reactive

The release of cytochrome C from the mitochondria leads to production of a caspase-activating complex of cytochrome c, APAF-1, and procaspase-9, triggers the up-regulation of caspase-9, and subsequently increases the expression of caspase-3, followed by the induction of apoptotic events in the cell [44]

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Chen, Q., Lu, H

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