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Adverse Reactions/Side Effects Oxalate, urate, or cystine renal stones causing renal tubular obstruction, characterized by costovertebral pain or lower back pain, can occur following large doses of ascorbic acid

While this decline could be attributed to multiple factorschanging social norms, economic pressures, or generational shiftsthe timing aligns closely with the rise of these medications

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Kamata H, Hirata H, Redox regulation of cellular signaling, Cell Signal

10.1038/ijo.2012.227 97 Perez-TilveD.Gonzalez-MatiasL.AulingerB

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