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RAASis with the maximally recommended or maximally tolerated dose of ACEi or ARB are the standard of care for prevention and treatment of CKD in people with diabetes, and they provide benefit over and above the effect of controlling BP [13]

As patents are provided with 20 years of protection from the date of filing once granted, these patents should technically expire on March 20, 2026 (see Figure 8)

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This is why dose escalation is intentionally gradual in supervised programs