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Patients should seek immediate medical attention for severe hypoglycaemia, persistent abdominal pain (possible pancreatitis), or signs of diabetic ketoacidosis

Although not assessed in this small study, genetic polymorphisms of metformin uptake or excretion may explain the large interindividual variations in metformin concentrations but they have not been reliably linked to metformins glucose-lowering effects [36,37,38]

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