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One of the theories that tries to explain the exercise effects defends that it may be in part due to the accumulation of oxidative damage induced by reactive oxygen species (ROS) and reactive nitrogen species (RNS) to cells and macromolecules [13]

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Its three-amino-acid structure (Lys-Pro-Val) allows it to resist proteolytic degradation in the gut lumen, an unusual property that makes it valuable for gastrointestinal inflammation research

The inhibitor treatment group (DHEA + GPNA group) received daily subcutaneous injections of DHEA (600 mg/kg body weight) along with intraperitoneal injections of the inhibitor GPNA (200 mg/kg body weight, Selleck, TX, USA) every other day for 21 consecutive days