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Although animal models provide a more integrated physiological context, their translational value is limited by interspecies differences in copper metabolism and the difficulty in modelling human-specific gene-environment interactions [253]

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Cagrilintide is a long-acting amylin agonist that has 84% homology to native human amylin with several amino acid substitutions and other chemical alterations to enhance stability, potency and biological half-life [3, 6]