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Doi: 18

He notes that this approach can be especially helpful for patients who have had difficulty with other weight loss medications or who worry about digestive side effects

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The structure reveals a closed conformation in which the peptide-binding region of the ECD interacts with the extracellular regions of the TMD

The FDA granted traditional approval to Leqembi (lecanemab) in July 2023 after the Phase 3 CLARITYAD trial demonstrated clinically meaningful slowing of decline

While consensus does not exist regarding the exact synergistic mechanisms by which dual-agonists work, the addition of GIP agonism is posited to improve the HbA1c control and weight loss offered by GLP-1 agonists alone by enhancing insulin secretion, decreasing energy consumption, and stimulating satiety in the hypothalamus