glp-1 agonist mechanism Glucagon-like peptide 1 receptor agonists: cardiovascular benefits and mechanisms of action mechanism of action of glp

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doi: 10.1016/B978-0-12-813768-0.00026-8 13 GalanakisCM

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Redox homeostasis genes modulate response to APR-246 in a p53-dependent and p53-independent manner Previous studies have characterized APR-246 as a modulator of redox homeostasis and inducer of ROS through depletion of key antioxidants, resulting in both p53-dependent and -independent cell death pathways such as ferroptosis [26,27,28,29]