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Retatrutide is not yet FDA approved, but like many GLP-1 agonists such as Wegovy (semaglutide) and Mounjaro (tirzepatide), retatrutide will most likely be a weekly injection, delivered subcutaneously into the arm, thigh or stomach area in a self-inject pen

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Figure 2: AMPA and NMDA receptor levels following 40 ng/ml dose of IGF-1 DES

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L.ZeffiroT.HaslerG.et al (2014)

These findings emphasize the importance of systemic vascular function and mechanics on long term brain health, likely mediated by damage and mechanical stress on cerebral microvasculature