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doi: 10.1038/s41467-021-26437-y 31 ThanNGHahnSRossiSWSzekeres-BarthoJ

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In terms of vaccine design, maintaining the pre-fusion conformation of Env is an oft-encountered problem in the design of recombinant Env proteins as potential immunogens 27,28,29

It translocates to the nucleus and induces the production of anorectic neuropeptide POMC, while repressing the production of orexigenic neuropeptide AgRP