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Bariatric surgery remains the most effective long-term treatment for severe obesity, particularly for people with BMIs over 40 or those with significant health complications

Eli Lilly's retatrutide (LY3437943) was in Phase 3 trials as of 2025, with at least one stage expected to conclude in May 2026 [6]

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Am J Clin Nutr 51(5):759767

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Discussion l-carnitine (lysine + methionine) is involved in beta-oxidation [29]