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No head-to-head trial has compared the two, so every direct comparison here is cross-trial inference

Dual inhibition of Akt and c-Met as a second-line therapy following acquired resistance to sorafenib in hepatocellular carcinoma cells

Thiele GM, Duryee MJ, Anderson DR, Klassen LW, Mohring SM, Young KA, et al

Mol Cell Biochem 293:211219 Kamel MY, Ahmed SM, Abdelzaher WY, Welson NN, Abdel-Aziz AM (2022) Role of IL-6/STAT3 pathway in mediating the protective effect of agomelatine against methotrexate-induced lung/intestinal tissues damage in rats

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