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[50] observed oscillations of citrate in the mitochondria of rat islets and INS-1 cells in the presence of pyruvate and in intact INS-1 cells exposed to glucose

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The recent discovery of pharmacological ABHD5 ligands that disrupt the interaction between ABHD5 and PLIN1 (48) demonstrate that the dissociation of ABHD5 is sufficient to stimulate adipocyte lipolysis and that these protein interactions can be targeted pharmacologically (34, 48, 49)