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Dringen R. Metabolism and functions of glutathione in brain. Prog Neurobiol. 2000;62(6):649-671. doi:10.1016/s0301-0082(99)00060-x
Patients who are pregnant, breastfeeding, have complex medical conditions, untreated sleep disorders, cardiovascular concerns, psychiatric instability, autoimmune concerns, or multiple medication interactions should be especially cautious
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While gentle introduction is wise, some skin types can handle moderate concentrations from the start and don't benefit from extended time at minimal levels