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A Romanian randomized controlled trial including 62 VPA-poisoned patients admitted to the ICU (28 treated versus 34 non-treated patients with L-carnitine 1,800 mg/day for 3 days) reported that L-carnitine reduced plasma VPA levels and facilitated the decrease in plasma ammonia concentrations [27]

doi: 10.3892/etm.2018.5719 113 LeeH-SLimW-CLeeS-JLeeS-HLeeJ-HChoH-Y

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FIGURE 2 Multiple RCTs, in more than 3,700 IBS-D or IBS-M patients, have demonstrated that alosetron significantly reduces abdominal pain and improves stool consistency compared to placebo (Table 4)

Long-term use over 12-24 week cycles in anecdotal reports from research users in Canada shows consistent improvements in body composition, particularly in the visceral fat compartment