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BPC-157 has demonstrated systemic activity when administered orally (in some models), though subcutaneous delivery is most commonly used in the published literature

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In vivo evidence is limited to a murine tooth extraction model treated with lipopolysaccharide injection where TNF-a retarded bone regeneration [196]

In male mice even low-dose exposure to PS-MPs and PS-NPs (0.5 mg/day for 60 days) reduced Lactobacillus , a genus important for epithelial maintenance (Chen et al., 2023)