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(Gallstones can also result from rapid weight loss in the absence of GLP-1 medication.) Thyroid tumors: Animal studies have raised concerns about a potential link between GLP-1s and thyroid tumors, but ongoing surveillance has not shown that this applies to humans

Most recently, there are new indications for chronic kidney disease and sleep apnea

The New England journal of medicine, 393(1), 2636

They are now commonly used when: Metformin alone is no longer enough Weight gain is contributing to worsening glucose control There is a need to minimise hypoglycaemia risk Someone has existing cardiovascular disease or multiple risk factors For many people, GLP-1 therapy can delay or reduce the need for insulin, or allow insulin doses to be kept lower and safer

These effects help regulate blood sugar and make you feel fuller for longer, resulting in reduced calorie intake and subsequent weight loss

An increase in the incidence of cardiac arrhythmias, mainly supraventricular, was noted in some trial arms